We tested otub1, yod1, a20 all otu domain, cyld and usp5. Otulin protects the liver against cell death, inflammation. Deubiquitinasebased analysis of ubiquitin chain architecture. B schematic representation of mixed bone marrow chimera generation. Scientific, left 23 min to acclimate to the oct, and then frozen by submerging the. Get a special offer and listen to over 60 million songs, anywhere with amazon music unlimited. Otu deubiquitinases reveal mechanisms of linkage specificity. A g1 extract from helas3 cells was prepared and mixed with atp, ube2c, ube2s, and fluorescent. Cyld cleaves both k63 and m1 linkages komander et al. Deubiquitinasebased analysis of ubiquitin chain architecture using. Efficient apcc substrate degradation in cells undergoing mitotic exit depends on k11. By using our website and our services, you agree to our use of cooki. The beststudied otu enzymes are the ubchainediting enzyme a20, an.
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